The focus of precision nutrition is to personalize dietary intervention based on a person’s genetic information, lifestyle, and metabolic profile to mitigate chronic disease and enhance health outcomes. Precision nutrition takes content from nutrigenomics, metabolomics, and individualized health assessments so that dietary recommendations are not standardized. Precision nutrition can mitigate risk related to diabetes, cardiovascular disease, obesity, and metabolic syndrome. In addition, it provides potential interventions that are effective and sustained. This session will provide science behind personalized nutrition, its application in the clinical and public health settings, and how individual’s can use targeted dietary intervention employing evidence-based practices in pursuing better health outcomes over the long run.